Document 0516
 DOCN  M9650516
 TI    Infective complications after minor operations in patients infected with
       HIV: role of CD4 lymphocytes in prognosis.
 DT    9605
 AU    Emparan C; Iturburu IM; Portugal V; Apecechea A; Bilbao JE; Mendez JJ;
       Department of Surgery, Universidad del Pais Vasco, General; Surgery B,
       Hospital de Basurto, Bilbao, Spain.
 SO    Eur J Surg. 1995 Oct;161(10):721-3. Unique Identifier : AIDSLINE
       MED/96136956
 AB    OBJECTIVE: To find out the incidence of wound infection in patients with
       HIV and reduced counts of CD4 lymphocytes. DESIGN: Open study. SETTING:
       University hospital, Spain. SUBJECTS: 70 patients with HIV infection and
       enlarged lymph nodes. INTERVENTIONS: Biopsy of lymph nodes and
       withdrawal of a sample of blood for counts of CD4 lymphocytes and
       neutrophils. MAIN OUTCOME MEASURE: Development of infection at the
       biopsy site, and correlation of infecting organism with culture taken at
       the time of biopsy. RESULTS: Patients were divided into three groups
       depending on their CD4 count: more than 500 cells/ml (n = 26), 200-500
       cells/ml (n = 24), and less than 200 cells/ml (n = 20). Their neutrophil
       counts were 5.1, 3.8, and 2.5 x 10(9)/1, respectively. There were found
       four wound infections (6%); 2 were in the group with more than 500 CD4
       cells/ml, and these were caused by Staphylococcus aureus (which had been
       grown from nodes in 6 patients at the time of biopsy). The other 2 were
       in the group with less than 500 cells/ml and these were caused by
       Mycobacterium tuberculosis; cultures of the nodes had shown
       Staphylococcus epidermidis (n = 3) and M tuberculosis (n = 17). There
       were no infections in the group with 200-500 CD4 cells/ml, in which S
       epidermidis (n = 5) and M tuberculosis (n = 8) had been cultured from
       the lymph nodes. CONCLUSIONS: The CD4 count was of no prognostic
       importance in the development of wound infection, but severe depression
       of the CD4 count may increase the risk of atypical wound infections.
 DE    Biopsy  CD4 Lymphocyte Count  CD4-Positive T-Lymphocytes/*PHYSIOLOGY
       Human  HIV Infections/*IMMUNOLOGY  Leukocyte Count  Lymph
       Nodes/MICROBIOLOGY/PATHOLOGY  Neutrophils  Prognosis  Staphylococcal
       Infections/IMMUNOLOGY/MICROBIOLOGY  Surgical Wound
       Infection/*IMMUNOLOGY/MICROBIOLOGY  Tuberculosis/IMMUNOLOGY/MICROBIOLOGY
       JOURNAL ARTICLE

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