Document 0527
 DOCN  M9650527
 TI    Hepatitis C virus genotypes and severity of chronic liver disease in
       haemophiliacs.
 DT    9605
 AU    Tagariello G; Pontisso P; Davoli PG; Ruvoletto MG; Traldi A; Alberti A;
       Centre for Blood Diseases, Castelfranco Veneto Hospital, TV,; Italy.
 SO    Br J Haematol. 1995 Nov;91(3):708-13. Unique Identifier : AIDSLINE
       MED/96048918
 AB    We studied the activity and stage of chronic liver disease in 45
       HCV-seropositive/HIV-seronegative patients with severe haemophilia
       followed for at least 10 years. HCV-RNA was detected in serum in 36
       patients (80%) Viraemic cases were further analysed for HCV genotypes:
       10 (28%) were infected by type 1a, 10 (28%) by type 1b, seven (19%) by
       type 2, four (11%) by type 3, four (11%) had mixed infections (one by 1a
       + 1b, one by 1a + 2, one by type 2 + 3, and one by 1a + 2 + 3). ALT
       levels were within the normal range in 55% of the HCV-RNA negative
       patients but in only 11% of the viraemic cases. Results show a trend for
       higher levels of ALT in HCV-RNA-positive patients compared with those
       without viraemia (98 +/- 56 v 60 +/- 61), and particularly with patients
       with type 3 HCV infection (148 +/- 44). We suggest that a slow
       progression of chronic liver disease occurs in haemophilic
       HCV-positive/HIV-negative patients and conclude that presence of HCV-RNA
       in serum correlates well with cytolitic damage but, in the time-scale of
       our follow-up period, commonly used clinical-laboratory parameters
       cannot predict the chronic evolution of liver infection or identify
       differences in disease progression in relation to specific HCV subtypes.
 DE    Adolescence  Adult  Base Sequence  Child  Chronic Disease  Genotype
       Hemophilia/COMPLICATIONS/*VIROLOGY  Hepatitis C/COMPLICATIONS/GENETICS
       Hepatitis C Viruses/*GENETICS  Human  Liver
       Diseases/COMPLICATIONS/*VIROLOGY  Male  Middle Age  Molecular Sequence
       Data  RNA, Viral/GENETICS  Support, Non-U.S. Gov't  JOURNAL ARTICLE

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