Document 0528
 DOCN  M9650528
 TI    Persistent hepatitis C virus RNA replication in haemophiliacs: role of
       co-infection with human immunodeficiency virus.
 DT    9605
 AU    Chambost H; Gerolami V; Halfon P; Thuret I; Michel G; Sicardi F;
       Rousseau S; Perrimond H; Cartouzou G; Service d'Hematologie Pediatrique,
       CHU Timone, Marseille,; France.
 SO    Br J Haematol. 1995 Nov;91(3):703-7. Unique Identifier : AIDSLINE
       MED/96048917
 AB    In order to evaluate the evolution of transfusional hepatitis C in
       haemophiliacs, we performed a retrospective study of ALT levels and HCV
       viraemia with a RNA PCR assay in 57 patients. We found that the vast
       majority of HCV-infected patients remained viraemic (43/57 = 75%) and
       higher ALT levels correlated with HCV viraemia. Although indicators of
       the transfusional viral load (age, severity of haemophilia) and HBV
       co-infection did not correlate with HCV RNA replication, HIV
       seropositivity was strongly associated with persistence of HCV viraemia
       (23/25 = 92% in HIV-positive versus 20/32 = 62% in HIV-negative
       patients), without any correlation with CD4 counts. Genotyping of HCV in
       the 43 viraemic patients shows more frequent genotype 1 in the
       HIV-seropositive group (14/23) than in the seronegative group (6/20).
       Our data emphasize that besides the role of the immunodeficiency status,
       the genotypes of HCV might be involved in the differences observed in
       terms of HCV RNA replication between the HIV-seropositive and
       seronegative haemophiliacs.
 DE    Adolescence  Adult  AIDS-Related Opportunistic Infections/COMPLICATIONS
       Child  Hemophilia/*VIROLOGY  Hepatitis C/*COMPLICATIONS/VIROLOGY
       Hepatitis C Viruses/GENETICS/*ISOLATION & PURIF  Human  HIV
       Infections/*COMPLICATIONS/VIROLOGY  HIV Seropositivity  Middle Age
       Polymerase Chain Reaction  Retrospective Studies  RNA, Viral/*ISOLATION
       & PURIF  Support, Non-U.S. Gov't  Virus Replication  JOURNAL ARTICLE

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