Document 0550
 DOCN  M9650550
 TI    HIV type 1 extracellular Tat protein stimulates growth and protects
       cells of BK virus/tat transgenic mice from apoptosis.
 DT    9605
 AU    Campioni D; Corallini A; Zauli G; Possati L; Altavilla G;
       Barbanti-Brodano G; Institute of Microbiology, School of Medicine,
       University of; Ferrara, Italy.
 SO    AIDS Res Hum Retroviruses. 1995 Sep;11(9):1039-48. Unique Identifier :
       AIDSLINE MED/96089211
 AB    Cells from BKV/tat transgenic mice were characterized for their
       tumorigenic phenotype in nude and syngeneic BDF mice. The results
       indicate that the BKV/tat recombinant transgene has a weak tumorigenic
       potential, mostly predisposing to oncogenesis, and that second events
       are required for the development of tumorigenicity. Tat is endogenously
       produced and released by tumor cells. It is taken up by recipient cells
       directly from the culture medium, without need of cell to cell contact.
       Extracellular Tat stimulates proliferation of cells from BKV/tat
       transgenic mice and protects them from apoptosis under conditions of
       serum starvation. Our results are in agreement with a model in which Tat
       induces its effects on target cells in two different ways. Growth
       promotion may require interaction of extracellular Tat with surface
       receptors eliciting a signal for cell proliferation, whereas
       intranuclear localization of Tat is necessary for transactivation of
       viral and cellular genes.
 DE    Animal  Apoptosis  Cell Division  Cell Line  Cell Transformation,
       Neoplastic  Gene Products, tat/GENETICS/*PHYSIOLOGY  Genes, tat  Growth
       Substances/PHYSIOLOGY  HIV-1/GENETICS/*PHYSIOLOGY/PATHOGENICITY  Mice
       Mice, Inbred BALB C  Mice, Nude  Mice, Transgenic  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).