Document 0554
 DOCN  M9650554
 TI    HIV acquires functional adhesion receptors from host cells.
 DT    9605
 AU    Guo MM; Hildreth JE; Department of Pharmacology and Molecular Sciences,
       Johns Hopkins; University School of Medicine, Baltimore, Maryland 21205,
       USA.
 SO    AIDS Res Hum Retroviruses. 1995 Sep;11(9):1007-13. Unique Identifier :
       AIDSLINE MED/96089207
 AB    CD4 is known to serve as the principal cellular receptor for HIV.
       However, several observations suggest that other molecules may be
       involved in infection of cells by HIV. Cell adhesion molecules and their
       ligands expressed on HIV-susceptible cells have been implicated in the
       biology of HIV in a number of studies. We have recently reported that
       HIV and SIV acquire cell adhesion molecules from host cells. We now
       report that a specific cell adhesion molecule, CD44, that is acquired by
       HIV retains its biological activity when expressed on the virus. We
       tested CEMx174 cells, which are CD4-positive and HIV-susceptible for
       phorbol ester-inducible binding to hyaluronic acid through CD44. Phorbol
       ester-stimulated but not unstimulated CEMx174 cells bound hyaluronic
       acid. Likewise, HIV from stimulated cells but not from unstimulated
       cells bound hyaluronic acid through acquired CD44 molecules. This is the
       first demonstration that adhesion molecules acquired by HIV are
       functional and the results imply that HIV may have the capacity to bind
       to any cell or substrate that its host cell binds to. The demonstration
       of functional adhesion receptors on HIV has important implications with
       respect to the tropism, infectivity, and dissemination of HIV.
 DE    Antigens, CD44/*PHYSIOLOGY  Cell Adhesion/DRUG EFFECTS/PHYSIOLOGY  Cell
       Adhesion Molecules/PHYSIOLOGY  Cell Line  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY/METABOLISM/VIROLOGY  Human  Hyaluronic
       Acid/METABOLISM  HIV/*PHYSIOLOGY/PATHOGENICITY  Models, Biological
       Receptors, HIV/*PHYSIOLOGY  Support, U.S. Gov't, P.H.S.
       Tetradecanoylphorbol Acetate/PHARMACOLOGY  JOURNAL ARTICLE

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