Document 0571
 DOCN  M9650571
 TI    Maintenance of high virus load even after seroconversion in newborn cats
       acutely infected with feline immunodeficiency virus.
 DT    9605
 AU    Tokunaga K; Shoda K; Nishino Y; Mori S; Zhong Q; Zheng YH; Kishi M;
       Ishihara C; Kanda M; Ikuta K; Section of Serology, Institute of
       Immunological Science, Hokkaido; University, Sapporo, Japan.
 SO    Vaccine. 1995;13(15):1393-8. Unique Identifier : AIDSLINE MED/96145953
 AB    The viral loads in adult and newborn cats have been compared following
       injection with feline CD4+ FeL-039 line cells acutely infected with
       feline immunodeficiency virus (FIV). The level of virus genome in
       peripheral blood mononuclear cells (PBMC) increased progressively
       despite seroconversion in the newborn cats, whereas the virus genome was
       apparently cleared after seroconversion in the adult cats.
       Immunohistochemical staining of thymus of the FIV-infected newborn cats
       showed clusters of viral antigen-positive cells. These results indicate
       that FIV infection of the newborn cat results in higher virus loads than
       infection of the adult cat. We discuss these findings in relation to FIV
       as a model system for studies of the infection of neonates with an
       immunosuppressive retrovirus.
 DE    Acute Disease  Animal  Animals, Newborn/GROWTH & DEVELOPMENT/*VIROLOGY
       Antibodies, Viral/*BIOSYNTHESIS/*BLOOD  Antigens, Viral/BLOOD  Base
       Sequence  Cats  Feline Acquired Immunodeficiency
       Syndrome/ETIOLOGY/*VIROLOGY  Genome, Viral  Immunodeficiency Virus,
       Feline/GENETICS/*IMMUNOLOGY/PHYSIOLOGY  Leukocytes, Mononuclear/VIROLOGY
       Molecular Sequence Data  Polymerase Chain Reaction  Support, Non-U.S.
       Gov't  Thymus Gland/VIROLOGY  Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).