Document 0579
 DOCN  M9650579
 TI    Immunohistologic studies on subpopulations of lymphocytes in cattle with
       enzootic bovine leukosis.
 DT    9605
 AU    Chiba T; Hiraga M; Aida Y; Ajito T; Asahina M; Wu D; Ohshima K; Davis
       WC; Okada K; Department of Veterinary Pathology, Faculty of Agriculture,
       Iwate; University, Morioka, Japan.
 SO    Vet Pathol. 1995 Sep;32(5):513-20. Unique Identifier : AIDSLINE
       MED/96090824
 AB    The distribution of subpopulations of lymphocytes in lymph nodes and
       tumors from cattle with enzootic bovine leukosis (EBL) was examined by
       immunohistochemistry using a panel of monclonal antibodies against
       leukocyte differentiation molecules of EBL. The lesions in lymph nodes
       could be divided into three types based on the extent of infiltration
       and proliferation of neoplastic cells with provirus and differential
       expression of leukocyte differentiation molecules. The number of B-B2+,
       sIgM+ cells was reduced in frequency in follicles during the neoplastic
       cell proliferation. CD4- and CD8-positive alpha/beta T cells and
       gamma/delta T cells positive for WC1 (workshop cluster designation) were
       also reduced in frequency in areas infiltrated with neoplastic cells.
       Almost all neoplastic cells were B-B2- and IgM-positive. However, there
       were a few B-B2- and/or IgM-negative cells or cells stained faintly in
       all cases. WC1+ cells were not observed in tumor tissues. However, CD4+
       and CD8+ cells were observed throughout tumor tissues, suggesting a role
       for these cells in tumor immunity.
 DE    Animal  Antibodies, Monoclonal  Blotting, Southern/VETERINARY  Cattle
       Cell Differentiation/IMMUNOLOGY  Cervix Uteri/PATHOLOGY  CD4-CD8
       Ratio/VETERINARY  Electrophoresis, Polyacrylamide Gel/VETERINARY
       Enzootic Bovine Leukosis/IMMUNOLOGY/*PATHOLOGY  Female
       Immunohistochemistry  Leukemia Virus, Bovine/IMMUNOLOGY  Lymph
       Nodes/IMMUNOLOGY/PATHOLOGY  Lymphoma,
       Diffuse/IMMUNOLOGY/PATHOLOGY/VETERINARY  Support, Non-U.S. Gov't
       T-Lymphocyte Subsets/*PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).