Document 0590
 DOCN  M9650590
 TI    Intestinal T lymphocytes.
 DT    9605
 AU    Robijn RJ; Logtenberg T; Wiegman LJ; van Berge Henegouwen GP; Houwen RW;
       Koningsberger JC; Dept. of Gastroenterology, Immunology, University
       Hospital; Utrecht, The Netherlands.
 SO    Scand J Gastroenterol Suppl. 1995;212:23-33. Unique Identifier :
       AIDSLINE MED/96117908
 AB    The intestine is largely colonized by bacteria and further exposed to an
       immense array of ingested and shed immunogenic material. Therefore, the
       gut associated lymphoid tissue plays a major role in the human immune
       system. It may even constitute a unique immune system of its own, since
       it has been demonstrated to differ anatomically, phenotypically,
       functionally and on a molecular basis from its systemic counterpart and
       other peripheral lymphoid tissue. This is ultimately reflected by the
       observation in (transgenic) mice that intraepithelial T cells can
       develop independently of the thymus. Along the same lines, a rapidly
       growing body of evidences suggests that human bone marrow precursors can
       home to the gut epithelium, rearrange their T cell receptor genes and
       further differentiate in the mucosal micro environment. This, and other
       features that characterize the 'diffuse' mucosal T cell infiltrate will
       be discussed.
 DE    Animal  CD4-Positive T-Lymphocytes/IMMUNOLOGY/METABOLISM/PHYSIOLOGY
       CD8-Positive T-Lymphocytes/IMMUNOLOGY/METABOLISM/PHYSIOLOGY  Gene
       Rearrangement, T-Lymphocyte  Human  Intestinal
       Mucosa/*IMMUNOLOGY/METABOLISM/PHYSIOLOGY  Mice  Mice, Transgenic
       Receptors, Antigen, T-Cell  Support, Non-U.S. Gov't  T-Lymphocyte
       Subsets  *T-Lymphocytes/IMMUNOLOGY/METABOLISM/PHYSIOLOGY  JOURNAL
       ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).