Document 0594
 DOCN  M9650594
 TI    Possible role of bovine immunodeficiency virus in bovine paraplegic
       syndrome: evidence from immunochemical, virological and seroprevalence
       studies.
 DT    9605
 AU    Walder R; Kalvatchev Z; Tobin GJ; Barrios MN; Garzaro DJ; Gonda MA;
       Laboratorio Virus Animales, Instituto Venezolano de; Investigaciones
       Cientificas (IVIC), Caracas.
 SO    Res Virol. 1995 Sep-Oct;146(5):313-23. Unique Identifier : AIDSLINE
       MED/96151048
 AB    Bovine paraplegic syndrome (BPS) is a debilitating cattle disease of
       unknown origin that is characterized by leukocytosis, lymphocytopenia
       and monocytopenia. The major clinical signs are difficulties in
       locomotion affecting hind limbs, hypoalgesia in the hind quarters,
       posterior paralysis and death within 72 to 96 hours after recumbency. To
       investigate the aetiological basis of BPS, we examined a possible
       association of the syndrome with infection by bovine immunodeficiency
       virus (BIV), a lentivirus implicated in immune system dysfunction and
       central nervous system lesions in cattle. Serum samples (n = 1,278) were
       collected from both healthy and BPS-prevalent cattle herds in Venezuela,
       and organ extracts were prepared from euthanized animals (n = 11)
       suspected of having BPS. Sera were analysed for reactivity to
       recombinant BIV and bovine leukaemia virus gag precursor proteins by
       immunoblot procedures. Serum reactivity to BIV ranged from 12 to 66%
       between groups of BPS prevalent herds. The percentage of samples
       reactive to BLV antigen was much lower (2 to 17%). Rabbits inoculated
       with extracts from BPS-afflicted animals exhibited an anamnestic immune
       response to BIV antigens as well as the presence of BIV gag antigens in
       their tissues. We present evidence for a possible association between
       BPS disease and a viral agent related to BIV. The role of BIV, in
       combination with malnutrition, in BPS is discussed.
 DE    Animal  Antibodies, Viral/BLOOD  Cattle  Cattle
       Diseases/IMMUNOLOGY/*VIROLOGY  Cell Line  Immunodeficiency Virus,
       Bovine/IMMUNOLOGY/ISOLATION & PURIF/  *PHYSIOLOGY  Lentivirus
       Infections/BLOOD/COMPLICATIONS/IMMUNOLOGY/*VETERINARY  Leukemia Virus,
       Bovine/IMMUNOLOGY  Paraplegia/BLOOD/IMMUNOLOGY/*VETERINARY/VIROLOGY
       Rabbits  Support, Non-U.S. Gov't  Syndrome  Venezuela  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).