Document 0602
 DOCN  M9650602
 TI    Tuberculosis and HIV infection worldwide.
 DT    9605
 AU    Murray JF; Division of Pulmonary and Critical Care Medicine, San
       Francisco; General Hospital Medical Center, University of California,
       USA.
 SO    Pneumologie. 1995 Dec;49 Suppl 3:653-6. Unique Identifier : AIDSLINE
       MED/96147392
 AB    The incidence of HIV-associated tuberculosis is increasing worldwide and
       will continue to increase during the foreseeable future, especially in
       developing countries. HIV infection appears to increase the opportunity
       for M. tuberculosis to succeed in causing infection after inhalation
       into the lungs. Moreover, there is persuasive evidence that in the
       presence of HIV infection, new-onset tuberculous infection will progress
       rapidly to clinically significant disease and the likelihood that latent
       tuberculous infection will reactivate is enormously increased. The
       accelerating and amplifying influence of HIV infection is contributing
       to the increasing incidence of disease caused by multidrug-resistant
       strains of M. tuberculosis. Neither clinical or radiographic features
       reliably distinguish the majority of patients with HIV-associated
       tuberculosis from those who are non-HIV-infected. The remainder,
       however, may have atypical manifestations and be difficult to diagnose.
       Six months of chemotherapy with conventional antituberculosis drugs
       cures most patients, but many die during or after treatment of other
       AIDS-related complications.
 DE    AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY/PREVENTION &
       CONTROL/TRANSMISSION  *Cross-Cultural Comparison  Cross-Sectional
       Studies  Developing Countries  Forecasting  Human  Incidence
       Tuberculosis, Multidrug-Resistant/EPIDEMIOLOGY/PREVENTION &
       CONTROL/TRANSMISSION  Tuberculosis, Pulmonary/*EPIDEMIOLOGY/PREVENTION &
       CONTROL/  TRANSMISSION  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).