Document 0606
 DOCN  M9650606
 TI    Clinical significance of resolution of chest X-ray findings in
       HIV-infected children with lymphocytic interstitial pneumonitis (LIP).
 DT    9605
 AU    Prosper M; Omene JA; Ledlie; Odita JC; Department of Pediatrics,
       Woodhull Medical and Mental Health; Center, 760 Broadway, Brooklyn, NY
       11206, USA.
 SO    Pediatr Radiol. 1995 Nov;25 Suppl 1:S243-6. Unique Identifier : AIDSLINE
       MED/96171724
 AB    Lymphocytic interstitial pneumonitis (LIP) in HIV-infected children is
       generally associated with better prognosis as compared with children
       with Pneumocystis carinii pneumonia (PCP). We prospectively studied 12
       cases of HIV-infected children with LIP over a 4-year period in an
       effort to document one aspect of the natural history of this clinical
       entity. Severe CD4 lymphocytopenia was associated with complete
       resolution of the chest X-ray findings in five patients, one of whom
       died of disseminated Mycobacterium avium complex. A second patient
       developed rapid-onset subacute HIV encephalopathy at the time when the
       CD4-lymphocyte count declined from 589 to 39, and the lung findings
       resolved spontaneously. The resolution of the lung pathology may be the
       first indication of severe immune suppression and a warning of the
       increased risk for opportunistic infections. Therefore, in those
       settings where diagnostic laboratory facilities are not easily
       available, the resolution of the reticulonodular changes on chest
       radiographs is a poor prognostic sign in HIV-infected children with LIP.
 DE    AIDS-Related Opportunistic Infections/EPIDEMIOLOGY  Child  Child,
       Preschool  CD4 Lymphocyte Count  Female  Human  HIV
       Infections/EPIDEMIOLOGY/IMMUNOLOGY/*RADIOGRAPHY  Lung/RADIOGRAPHY  Lung
       Diseases, Interstitial/EPIDEMIOLOGY/IMMUNOLOGY/*RADIOGRAPHY  Male
       Prognosis  Prospective Studies  Risk Factors  JOURNAL ARTICLE

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