Document 0608
 DOCN  M9650608
 TI    A new approach to antiviral therapy.
 DT    9605
 AU    Peuschel KE
 SO    Med Hypotheses. 1995 Oct;45(4):375-9. Unique Identifier : AIDSLINE
       MED/96153542
 AB    A new approach to antiviral therapy is proposed, taking advantage of the
       recently investigated innervation of immune tissues by the sympathetic
       nervous system, which establishes a functional connection between the
       nervous and the immune system, where the sympathetic nervous system
       exerts a varying tonic inhibitory influence on cellular activation via
       secretion of norepinephrine and reception thereof by beta-receptors on
       leukocytes. Simultaneous beta-adrenergic blockade of leukocytes and
       stress-related centres of the central nervous system (paraventricular
       nucleus of the hypothalamus) is suggested as immunoactivating therapy in
       presence of foreign antigen. Immunoactivation is newly defined as
       facilitated activation of the immune system in presence of foreign
       antigen and is theoretically correlated with indirect antiviral and
       antitumoral activity.
 DE    Adjuvants, Immunologic/*THERAPEUTIC USE  Adrenergic
       beta-Antagonists/*THERAPEUTIC USE  Adult  Child  Cyclic AMP/PHYSIOLOGY
       Human  Hypothalamo-Hypophyseal System/PHYSIOPATHOLOGY  HIV
       Infections/THERAPY  Leukocytes/PHYSIOLOGY  *Neuroimmunomodulation
       Norepinephrine/PHYSIOLOGY  Paraventricular Hypothalamic
       Nucleus/PHYSIOLOGY  Pituitary-Adrenal System/PHYSIOPATHOLOGY  Receptors,
       Adrenergic, beta/PHYSIOLOGY  Stress/PHYSIOPATHOLOGY  Sympathetic Nervous
       System/PHYSIOLOGY  Virus Diseases/IMMUNOLOGY/PHYSIOPATHOLOGY/*THERAPY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).