Document 0629
 DOCN  M9650629
 TI    Disseminated Encephalitozoon (Septata) intestinalis infection in a
       patient with AIDS: novel diagnostic approaches and autopsy-confirmed
       parasitological cure following treatment with albendazole.
 DT    9605
 AU    Sobottka I; Albrecht H; Schafer H; Schottelius J; Visvesvara GS; Laufs
       R; Schwartz DA; Department of Medicine, University Hospital Eppendorf,
       Hamburg,; Germany.
 SO    J Clin Microbiol. 1995 Nov;33(11):2948-52. Unique Identifier : AIDSLINE
       MED/96121246
 AB    Encephalitozoon intestinalis is a recently described microsporidian
       which causes intestinal and disseminated infections in severely
       immunocompromised patients with AIDS. Preliminary data suggest that
       albendazole can be an effective therapy for patients with E.
       intestinalis infection. However, relapses have been reported following
       treatment in some cases. These results were based upon examination of
       cytologic, biopsy, or stool samples with an inherent sampling bias. This
       report documents the first postmortem evaluation of a patient with E.
       intestinalis infection treated with albendazole. Antemortem
       microsporidial diagnosis was performed on nasal mucosal smear and
       duodenal biopsy specimens by electron microscopy and a newly developed
       indirect fluorescent-antibody method based upon in vitro cultivation of
       the organism. This case represents the initial report of using nasal
       cytologic specimens for ultrastructural and antibody-based species-level
       diagnosis of microsporidiosis. Following successful treatment of this
       infection with albendazole, the patient died of other causes. A thorough
       autopsy examination failed to reveal the presence of E. intestinalis in
       any tissue, providing confirmatory evidence for a complete
       parasitological cure with albendazole.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PARASITOLOGY  Adult
       Albendazole/*THERAPEUTIC USE  Animal  Antiprotozoal Agents/*THERAPEUTIC
       USE  Autopsy  Case Report  Duodenum/PARASITOLOGY
       Encephalitozoonosis/COMPLICATIONS/*DIAGNOSIS/*DRUG THERAPY
       Feces/PARASITOLOGY  Fluorescent Antibody Technique, Indirect  Human
       Male  Mucus/PARASITOLOGY  Treatment Outcome  Urine/PARASITOLOGY  JOURNAL
       ARTICLE

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