Document 0632
 DOCN  M9650632
 TI    CD4+ Th2 cell response cytokine production in bacterial meningitis.
 DT    9605
 AU    Raziuddin S; el-Awad ME; Telmesani AW; Bilal NE; al-Janadi M; King
       Faisal Specialist Hospital & Research Center, Riyadh, Saudi; Arabia.
 SO    J Clin Immunol. 1995 Nov;15(6):338-48. Unique Identifier : AIDSLINE
       MED/96159700
 AB    There has been a growing body of evidence suggesting that CD4+ Th1/Th2
       cell responses participate in pathologic and immunologic processes in
       infectious disease. Bacterial meningitis is a fatal disease of children
       and is associated with a spectrum of clinical syndromes. This study
       provides evidence of CD4+ enhanced interleukin (IL)-4 and IL-6 but
       decreased IL-2 and interferon-gamma (IFN-gamma) production, the
       induction of characteristic Th2 cell response cytokines in bacterial
       meningitis, which may play an important role in disease mechanism.
       Additionally, monocyte-induced enhanced IL-6, IL-8, and tumor necrosis
       factor-alpha production may be associated with distinct clinical
       features such as fever, seizures, and neurological sequelae. A striking
       finding was also the highly deficient monocyte-induced
       granulocyte-macrophage colony-stimulating factor production. Of
       particular interest, the CD(8+)-enhanced IFN-gamma production may be
       required for the cytolytic activity or protective response to be
       maintained in this disease. Taken together, these data reveal that
       monocytes and CD4+ (Th2) and CD8+ subsets produce distinct cytokines in
       bacterial meningitis, which may exert an immunoregulatory and
       immunopathologic effect and thus mediate some of the clinical
       manifestations of the disease.
 DE    Cells, Cultured  Child  Child, Preschool
       Cytokines/*BIOSYNTHESIS/SECRETION  CD8-Positive
       T-Lymphocytes/CLASSIFICATION/METABOLISM  Female  Human  Male
       Meningitis, Bacterial/ETIOLOGY/*IMMUNOLOGY
       Monocytes/IMMUNOLOGY/METABOLISM  Th2 Cells/*IMMUNOLOGY/*METABOLISM
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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