Document 0633
 DOCN  M9650633
 TI    Inhibitory effect of the immunosuppressant FK506 on apoptotic cell death
       induced by HIV-1 gp120.
 DT    9605
 AU    Sekigawa I; Koshino K; Hishikawa T; Kaneko H; Takasaki Y; Hashimoto H;
       Hirose S; Inagaki Y; Yamamoto N; Department of Medicine, Juntendo
       University, School of Medicine,; Tokyo, Japan.
 SO    J Clin Immunol. 1995 Nov;15(6):312-7. Unique Identifier : AIDSLINE
       MED/96159697
 AB    Human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120
       may play a central role in inducing immunoregulatory disorders after HIV
       infection. The apoptotic death of normal human peripheral blood
       mononuclear cells was induced by priming with gp120 followed by
       stimulation with an anti-T cell receptor (TCR) antibody. Tumor necrosis
       factor-alpha produced by gp120-binding macrophages may be important to
       induce this cell death. Treatment of gp120-primed cells with an
       immunosuppressant (FK506) before TCR signaling inhibited apoptotic cell
       death, and this blocking effect of FK506 was concentration dependent.
       FK506 did not have any influence on cell growth and viability over the
       range of concentrations tested. These findings suggest that FK506 is a
       potentially useful drug in delaying the onset of AIDS after HIV
       infection.
 DE    Antiviral Agents/PHARMACOLOGY  Apoptosis/*DRUG EFFECTS  Cells, Cultured
       Human  HIV Envelope Protein gp120/*TOXICITY  HIV-1/DRUG
       EFFECTS/*PHYSIOLOGY  Immunosuppressive Agents/*PHARMACOLOGY  Leukocytes,
       Mononuclear/DRUG EFFECTS/VIROLOGY  Protein Binding/DRUG EFFECTS
       Tacrolimus/*PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).