Document 0642
 DOCN  M9650642
 TI    CD8+ T cell subsets in aging.
 DT    9605
 AU    Ruiz M; Esparza B; Perez C; Barranquero M; Sabino E; Merino F; School of
       Medicine, Universidad del Pais Vasco, Leioa, Vizcaya,; Spain.
 SO    Immunol Invest. 1995 Nov;24(6):891-5. Unique Identifier : AIDSLINE
       MED/96153654
 AB    Infections are major cause of illness and death amongst elderly people.
       Peripheral blood CD8+ T lymphocytes -which play a crucial role in host
       defence against viral infections-. are divided in subsets based upon the
       expression of several cell and activation markers. Since in senescence
       changes in peripheral blood CD8+ T lymphocyte compartment have been
       described, studies were performed to determine whether in aging there
       are variations in the peripheral blood CD8+CD38+, CD8+CD57+,
       CD8+HLA-DR+, CD8+CD45RA+ and CD8+CD45RO+ cell subset. A decrease in the
       CD8+CD45RA+ lymphocytes was observed, indicating that variations in the
       CD8+ compartment can take place with ageing.
 DE    Adult  Aged  Aged, 80 and over  Aging/*IMMUNOLOGY  Antigens,
       CD45/ANALYSIS  Antigens, CD57/ANALYSIS  Antigens,
       Differentiation/ANALYSIS  CD4-Positive T-Lymphocytes/IMMUNOLOGY
       CD8-Positive T-Lymphocytes/*CLASSIFICATION  Female  Human  HLA-DR
       Antigens/ANALYSIS  Immunophenotyping  Male  Middle Age
       Nucleosidases/ANALYSIS  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).