Document 0643
 DOCN  M9650643
 TI    Retrovirus-induced lymphoproliferative disease in mice undergoing
       graft-versus-host reaction.
 DT    9605
 AU    Cunningham RK; Thacore HR; Zhou P; Nakeeb S; Zaleski MB; Ernest Witebsky
       Center for Immunology, School of Medicine and; Biomedical Sciences,
       State University of New York, Buffalo; 14214-3078, USA.
 SO    Immunol Invest. 1995 Nov;24(6):881-90. Unique Identifier : AIDSLINE
       MED/96153653
 AB    The effect of graft-versus-host reaction on the course of concommitant
       retrovirus-induced lymphoproliferative disease was investigated. The
       graft-versus-host reaction was elicited by a single i.v. injection of
       1.2 x 10(8) parental spleen cells into adult F1 mice.
       Lymphoproliferative disease was induced by a single transfusion of 0.2
       ml of whole blood from donors with fully developed disease, induced by
       infection with retrovirus LP-BM5 MuLV. Graft-versus-host reaction and
       the lymphoproliferative disease each separately produced similar
       syndrome consisting of splenomegaly, lymphadenopathy, leukopenia,
       neutrophilia, reduced in vitro proliferation of spleen cells and
       suppression of in vivo immune responsiveness. The above symptoms were
       usually less pronounced during graft-versus-host reaction. Ongoing
       graft-versus-host reaction neither aggravated nor accelerated the course
       of the virus-induced lymphoproliferative disease in genetically
       susceptible F1 hybrids. Likewise, an ongoing graft-versus-host reaction
       in genetically resistant F1 hybrids did not alter their susceptibility
       to the retrovirus infection. The apparent lack of the effect of
       graft-versus-host reaction -dependent immunosuppression on the severity
       and the course of the concommitant retrovirus-induced
       lymphoproliferative disease suggests pathogenic differences between the
       murine syndrome and human AIDS for which the murine disease is
       considered by some to be an animal model.
 DE    Animal  Comparative Study  Graft vs Host
       Disease/COMPLICATIONS/IMMUNOLOGY/*VIROLOGY  *Leukemia Viruses, Murine
       Lymphocyte Transformation  Lymphoproliferative
       Disorders/*ETIOLOGY/IMMUNOLOGY/*VIROLOGY  Mice  Mice, Inbred C3H  Mice,
       Inbred C57BL  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).