Document 0651
 DOCN  M9650651
 TI    Anti-dorsalizing morphogenetic protein is a novel TGF-beta homolog
       expressed in the Spemann organizer.
 DT    9605
 AU    Moos M Jr; Wang S; Krinks M; Center for Biologics Evaluation and
       Research, Food and Drug; Administration, Rockville, MD 20852-1448, USA.
 SO    Development. 1995 Dec;121(12):4293-301. Unique Identifier : AIDSLINE
       GENBANK/U22155
 AB    We have identified a novel growth factor in Xenopus, which is most
       closely related to human Bone Morphogenetic Protein-3. Its expression
       peaks during gastrulation, most prominently in the Spemann organizer,
       and persists in the posterior neural floor plate and prechordal plate
       during neurulation. Injection of the corresponding mRNA into dorsal
       blastomeres results in dose-dependent suppression of dorsal and anterior
       structures, even in the presence of lithium chloride. Overexpression of
       the gene downregulates the dorsalizing factors noggin, goosecoid and
       follistatin, as well as the dorsal markers NCAM, muscle actin and MyoD;
       conversely, ventral markers are induced. We therefore designate this
       gene product Anti-Dorsalizing Morphogenetic Protein (ADMP). Though
       development of dorsoanterior structures is suppressed when exogenous
       ADMP is injected, the gene is induced by lithium chloride treatment or
       activin, both of which are known to produce the opposite effect. Thus,
       the expression of ADMP resembles that of several dorsalizing signals,
       but its product exerts dorsal-suppressing activity. This suggests that
       ADMP may moderate organizer-associated dorsalizing influences. These
       findings are also consistent with the recently advanced proposal of
       dorsally expressed inhibitory activin-like signals.
 DE    Amino Acid Sequence  Animal  Base Sequence  DNA Primers/GENETICS
       Gastrula/*PHYSIOLOGY  HIV Long Terminal Repeat  Mesoderm/PHYSIOLOGY
       Molecular Sequence Data  Nervous System/*EMBRYOLOGY  *Sequence Homology,
       Amino Acid  Transforming Growth Factor beta/*GENETICS
       Xenopus/*EMBRYOLOGY/GENETICS  JOURNAL ARTICLE

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