Document 0652
 DOCN  M9650652
 TI    The role of CD4 in HIV envelope-mediated pathogenesis.
 DT    9605
 AU    Siliciano RF; Department of Medicine, Johns Hopkins University School
       of; Medicine, Baltimore, MD 21205, USA.
 SO    Curr Top Microbiol Immunol. 1996;205:159-79. Unique Identifier :
       AIDSLINE MED/96148089
 AB    There is now compelling evidence that env-CD4 interactions are central
       to several complex pathogenic mechanisms in HIV-1 infection. In addition
       to mediating virus attachment to CD4+ cells, the high affinity
       interaction of env protein with CD4 is also important in initiating both
       syncytium formation and syncytium-independent cytopathic effects. In
       addition, shed gp120 can bind to CD4 on noninfected cells and interfere
       with the function of these cells while at the same time rendering the
       cells susceptible to destruction by ADCC, by CD4+ CTLs or by programmed
       cell death induced by cross-linking of CD4 with gp120 and anti-gp120
       followed by cellular activation. Although all of these mechanisms have
       been demonstrated to operate in vitro, it remains unclear how important
       each mechanism is in vivo. Nevertheless, the central role of env-CD4
       interactions in all of these pathogenic mechanisms highlights the
       importance of developing effective low molecular weight inhibitors of
       this reaction.
 DE    Animal  Antigens, CD4/*PHYSIOLOGY  Apoptosis  Gene Products,
       env/METABOLISM  Giant Cells/VIROLOGY  Human  HIV Antibodies/IMMUNOLOGY
       HIV Envelope Protein gp120/IMMUNOLOGY/*PHYSIOLOGY
       HIV-1/IMMUNOLOGY/*PHYSIOLOGY  Protein Precursors/METABOLISM
       T-Lymphocytes/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

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