Document 0660
 DOCN  M9650660
 TI    [Construction and expression of the gene CD4V1V2-PE40, coding for a
       molecular targeted protein against AIDS]
 DT    9605
 AU    Zhao X; Zhang M; Li H; Lu S; Institute of Medicinal Biotechnology, CAMS,
       Beijing.
 SO    Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao. 1995 Aug;17(4):248-52. Unique
       Identifier : AIDSLINE MED/96147920
 AB    We here replaced the cell-binding domain in Pseudomonas exotoxin A (PE)
       with HIV-binding portion of CD4V1V2 molecule and constructed a chimeric
       gene CD4V1V2-PE40, which can be expressed in E. coli. The hybrid protein
       displays targeting toxicity toward cells infected by HIV and thus
       represents a promising novel therapeutic agent for the treatment of
       AIDS.
 DE    *Acquired Immunodeficiency Syndrome  Antigens, CD4/*GENETICS  Antiviral
       Agents/PHARMACOLOGY  Bacterial Toxins/GENETICS  Cloning, Molecular
       English Abstract  Escherichia coli/GENETICS/*METABOLISM
       Exotoxins/*GENETICS  Gene Expression  Human  Plasmids  Pseudomonas
       aeruginosa  Recombinant Fusion Proteins/*BIOSYNTHESIS/PHARMACOLOGY
       SIV/DRUG EFFECTS  JOURNAL ARTICLE

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