Document 0662
 DOCN  M9650662
 TI    T-cell mediated rejection of gene-modified HIV-specific cytotoxic T
       lymphocytes in HIV-infected patients [see comments]
 DT    9605
 AU    Riddell SR; Elliott M; Lewinsohn DA; Gilbert MJ; Wilson L; Manley SA;
       Lupton SD; Overell RW; Reynolds TC; Corey L; Greenberg PD; Fred
       Hutchinson Cancer Research Center, Seattle, Washington; 98104, USA.
 SO    Nat Med. 1996 Feb;2(2):216-23. Unique Identifier : AIDSLINE MED/96160371
 CM    Comment in: Nat Med 1996 Feb;2(2):165-7
 AB    The introduction and expression of genes in somatic cells is an
       innovative therapy for correcting genetic deficiency diseases and
       augmenting immune function. A potential obstacle to gene therapy is the
       elimination of such gene-modified cells by an immune response to novel
       protein products of the introduced genes. We are conducting an
       immunotherapy trial in which individuals seropositive for human
       immunodeficiency virus (HIV) receive CD8+ HIV-specific cytotoxic T cells
       modified by retroviral transduction to express a gene permitting
       positive and negative selection. However, five of six subjects developed
       cytotoxic T-lymphocyte responses specific for the novel protein and
       eliminated the transduced cytotoxic T cells. The rejection of
       genetically modified cells by these immunocompromised hosts suggests
       that strategies to render gene-modified cells less susceptible to host
       immune surveillance will be required for successful gene therapy of
       immunocompetent hosts.
 DE    Antigen Presentation  Base Sequence  *Cytotoxicity, Immunologic
       CD8-Positive T-Lymphocytes/*IMMUNOLOGY/TRANSPLANTATION
       Histocompatibility Antigens Class I/IMMUNOLOGY  Human  HIV
       Antigens/*IMMUNOLOGY  HIV Infections/IMMUNOLOGY/*THERAPY
       *Immunotherapy, Adoptive  Molecular Sequence Data  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, P.H.S.  CLINICAL TRIAL  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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