Document 0669
 DOCN  M9650669
 TI    Mouse Eotaxin expression parallels eosinophil accumulation during lung
       allergic inflammation but it is not restricted to a Th2-type response.
 DT    9605
 AU    Ganzalo JA; Jia GQ; Aguirre V; Friend D; Coyle AJ; Jenkins NA; Lin GS;
       Katz H; Lichtman A; Copeland N; Kopf M; Gutierrez-Ramos JC; Center for
       Blood Research, Incorporated, Boston, Massachusetts; 02115, USA.
 SO    Immunity. 1996 Jan;4(1):1-14. Unique Identifier : AIDSLINE
       GENBANK/U40672
 AB    A model of lung eosinophilia based on the repeated exposure of mice to
       aerosolized OVA has been used to identify C-C chemokine genes expressed
       at stages of massive eosinophil infiltration. We describe the
       identification and cloning of a cDNA that encodes a mouse C-C chemokine
       with 68% amino acid identity to guinea pig Eotaxin. The recombinant
       protein encoded by this gene displays potent and specific chemotactic
       activity for eosinophils, both in vivo and in vitro. Its mRNA levels
       parallel the kinetics of eosinophil accumulation in the lung during the
       experimentally induced eosinophilia and it is mainly produced by type I
       alveolar epithelial cells. The mRNA expression of mouse Eotaxin is not
       restricted to Th2 T cells in vitro and is independent of the development
       of a Th2-type response during N. brasiliensis infection, in vivo.
 DE    Amino Acid Sequence  Animal  Base Sequence  Cell Movement  Cloning,
       Molecular  Cytokines/*BIOSYNTHESIS/GENETICS  DNA,
       Complementary/GENETICS/ISOLATION & PURIF
       Eosinophils/*IMMUNOLOGY/PATHOLOGY  Female
       Inflammation/IMMUNOLOGY/PATHOLOGY  Lung Diseases/*IMMUNOLOGY/PATHOLOGY
       Male  Mice  Mice, Inbred BALB C  Mice, Inbred C57BL  Molecular Sequence
       Data  Respiratory Hypersensitivity/IMMUNOLOGY  RNA, Messenger/*ANALYSIS
       Sequence Alignment  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Th2 Cells/*IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).