Document 0683
 DOCN  M9650683
 TI    Changes in serum antioxidant concentrations during infection with
       caprine lentivirus.
 DT    9605
 AU    Mdurvwa EG; Ogunbiyi PO; Reddy PG; Gakou HS; Sodeke SO; Carty AJ; Center
       for Biomedical Research/RCMI, Carver Research Foundation,; Tuskegee
       University, Alabama 36088, USA.
 SO    Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S65-72. Unique
       Identifier : AIDSLINE MED/96171636
 AB    We are currently using caprine arthritis encephalitis virus (CAEV)
       infection in goats as a model to understand changes in some clinical
       parameters and host response to infection with human immunodeficiency
       virus (HIV). The objective of this study was to measure changes in serum
       antioxidant activities in various age groups of goats infected with
       CAEV. Serum from CAEV-infected goats had significantly higher catalase
       activity (105.47 +/- 5.96 kU/l) than serum from healthy control goats
       (79.92 +/- 17.06 kU/l). Moreover, serum catalase activity increased with
       increase in the time after infection with CAEV. No change was observed
       in total superoxide dismutase (SOD) or glutathione peroxidase activity
       although CuZn SOD levels were elevated in infected goats. There was a
       positive correlation between serum catalase activity and hydrogen
       peroxide (H2O2) scavenging activity (r = 0.70, p < 0.05). In order to
       investigate cell membrane integrity, we determined lactate dehydrogenase
       (LDH) activity in infected goats. Although there was a transient
       increase in LDH no correlation was observed between increased serum
       catalase activity and LDH activity (r = 0.16, p > 0.05). We have earlier
       observed decreased oxyradical production in CAEV infected goats. This
       observed increase in serum catalase, a scavenger of endogenous free
       radicals such as H2O2 may be partly responsible for the observed
       decrease in oxygen radicals found in vivo.
 DE    Age Factors  Animal  Antioxidants/*ANALYSIS  *Arthritis-Encephalitis
       Virus, Caprine  Arthritis, Infectious/ENZYMOLOGY/*VETERINARY/VIROLOGY
       Cachexia/ENZYMOLOGY/VETERINARY/VIROLOGY  Catalase/*BLOOD  *Disease
       Models, Animal  Free Radical Scavengers  Glutathione Peroxidase/*BLOOD
       Goat Diseases/*BLOOD  Goats/BLOOD  Hydrogen Peroxide/BLOOD  *HIV
       Infections  Lactate Dehydrogenase/BLOOD  Lentivirus
       Infections/ENZYMOLOGY/*VETERINARY  Superoxide Dismutase/*BLOOD  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).