Document 0697
 DOCN  M9650697
 TI    Clinical utility of a new contrast option from magnetization transfer
       contrast.
 DT    9605
 AU    Gillams AR; Silver MS; Carter AP; Boston University Medical School, MA
       02118, USA.
 SO    J Magn Reson Imaging. 1995 Sep-Oct;5(5):545-50. Unique Identifier :
       AIDSLINE MED/96107641
 AB    Two magnetization transfer (MT) contrast effects, a T2-like effect and
       the improved contrast observed when gadolinium is used with MT, are
       combined in a single sequence. Forty patients (22 males:18 females; mean
       age, 45 years (23-87)) with suspected intracranial pathology underwent
       MRI on a 1.5 Tesla system. Of 46 lesions; seven were ischemic, five
       infective, seven neoplastic, four hemorrhagic, four multiple sclerosis,
       seven human immunodeficiency virus (HIV) leukoencephalopathy, nine
       normal/miscellaneous, and three gliosis. A conventional spin-echo
       sequence (TR 900 TE 15) was used with on-resonance binomial MT pulses.
       The sequence was performed postgadolinium +/- MT. The signal intensity
       ratios +/- MT were: white matter, 0.62 +/- 0.03; gray matter, 0.75 +/-
       0.04; ischemia, edema, and demyelination, 0.75 (0.57-0.86); and
       gadolinium/methemoglobin, 0.85 (0.81-0.98). Areas which exhibited MT had
       T2-like contrast and those that did not maintained expected contrast for
       the given parameters. The result was a combination of T2-like contrast,
       gadolinium enhancement, and dark cerebrospinal fluid (CSF) providing
       both increased sensitivity to lesions which exhibited both contrast
       features and improved delineation of periventricular lesions.
       Furthermore, the differential signal between T2-like contrast of edema
       and gadolinium enhancement in neoplastic or infective lesions was
       maintained.
 DE    Adult  Aged  Aged, 80 and over  Brain/PATHOLOGY  Brain
       Diseases/CEREBROSPINAL FLUID/*DIAGNOSIS/PHYSIOPATHOLOGY  Contrast
       Media/ADMINISTRATION & DOSAGE  Female  Gadolinium/*DIAGNOSTIC USE  Human
       *Image Enhancement  *Magnetic Resonance Imaging/INSTRUMENTATION/METHODS
       Male  Middle Age  Sensitivity and Specificity  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

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