Document 0726
 DOCN  M9650726
 TI    Regional distribution of lesions in the central nervous system of cats
       infected with feline immunodeficiency virus.
 DT    9605
 AU    Abramo F; Bo S; Canese MG; Poli A; Department of Animal Pathology,
       University of Pisa, Italy.
 SO    AIDS Res Hum Retroviruses. 1995 Oct;11(10):1247-53. Unique Identifier :
       AIDSLINE MED/96157214
 AB    Neuropathological examination of the central nervous system of 13
       naturally and 13 experimentally feline immunodeficiency virus
       (FIV)-infected cats revealed diffuse gliosis of gray and white matter
       and vacuolar myelinopathy in a large proportion of infected animals,
       sometimes associated with lymphocytic meningitis. Multinucleated giant
       cell formation, the hallmark of multifocal giant cell encephalitis in
       HIV infection, was never observed. Morphometric analysis confirmed a
       marked increase of GFAP reactivity in infected cats. Gliosis was mainly
       present in cortical structures of frontal, parietal, and occipital
       lobes. Only one naturally infected animal evidenced clinical symptoms of
       neurological damage. This study confirms that FIV provides an
       interesting model for studying HIV-induced cortical and subcortical
       brain pathology believed to be the cause of the neurological
       manifestations frequently observed in AIDS patients.
 DE    Animal  Cats  Central Nervous System/*PATHOLOGY  Feline Acquired
       Immunodeficiency Syndrome/*PATHOLOGY  Female  Immunodeficiency Virus,
       Feline/*PHYSIOLOGY  Male  Meninges/PATHOLOGY  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

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