Document 0733
 DOCN  M9650733
 TI    The genetic diversification of the HIV type 1 gag p17 gene in patients
       infected from a common source.
 DT    9605
 AU    Kasper P; Simmonds P; Schneweis KE; Kaiser R; Matz B; Oldenburg J;
       Brackmann HH; Holmes EC; Institut fur Medizinische Mikrobiologie und
       Immunologie,; Universitat Bonn, Germany.
 SO    AIDS Res Hum Retroviruses. 1995 Oct;11(10):1197-201. Unique Identifier :
       AIDSLINE GENBANK/U32149
 AB    An evolutionary analysis was undertaken of HIV-1 gag p17 sequences taken
       from a small cohort of hemophilia B patients infected from a common
       batch of clotting factor concentrate. The sequence population found at
       seroconversion was highly homogeneous, suggesting that the infecting
       batch also contained little sequence variation. Genetic diversification
       was found in follow-up sequences taken approximately 3 years later and
       was generally found to be complex. Greater rates of synonymous to
       nonsynonymous substitution were observed, especially when comparing
       distantly related isolates, and the rate of synonymous substitution was
       used to estimate times of divergence for a number of isolates of HIV-1
       including the origin of the subtypes A to H. The p17 region is therefore
       proposed as a useful marker for future epidemiological studies.
 DE    Amino Acid Sequence  Base Sequence  Blood Transfusion/ADVERSE EFFECTS
       Christmas Disease/COMPLICATIONS  Cohort Studies  Evolution  Follow-Up
       Studies  Gene Products, gag/*GENETICS  Human  HIV Antigens/*GENETICS
       HIV Infections/COMPLICATIONS/ETIOLOGY/*VIROLOGY  HIV-1/*GENETICS
       Molecular Sequence Data  Phylogeny  Sequence Homology, Amino Acid
       Variation (Genetics)  JOURNAL ARTICLE

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