Document 0737
 DOCN  M9650737
 TI    Random copolymers containing specific ratios of negatively charged and
       aromatic amino acids bind V3 disulfide loop and neutralize diverse HIV
       type 1 isolates.
 DT    9605
 AU    Javaherian K; McDanal C; Repligen Corporation, Cambridge, Massachusetts
       02139, USA.
 SO    AIDS Res Hum Retroviruses. 1995 Oct;11(10):1163-8. Unique Identifier :
       AIDSLINE MED/96157203
 AB    Random copolymers of polyamino acids containing negatively charged and
       aromatic residues at specific ratios appear to bind HIV type 1 V3 loop
       and neutralize diverse laboratory isolates. At least the putative
       heparin binding domain and isoleucine residues in the amino half of V3
       are involved in the interactions with these polymers. There are a number
       of interesting features common between these polymer's modes of binding
       to the V3 and the protease inhibition drug ABT-538.
 DE    Amino Acid Sequence  Amino Acids/CHEMISTRY  Disulfides/CHEMISTRY
       Electrochemistry  Human  HIV Envelope Protein gp120/CHEMISTRY/*DRUG
       EFFECTS  HIV-1/CHEMISTRY/*DRUG EFFECTS/ISOLATION & PURIF  Molecular
       Sequence Data  Peptide Fragments/CHEMISTRY/*DRUG EFFECTS
       Peptides/CHEMISTRY/PHARMACOLOGY  Polymers/CHEMISTRY/*PHARMACOLOGY
       Structure-Activity Relationship  Tumor Cells, Cultured  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).