Document 0767
 DOCN  M9650767
 TI    Prevention of recurrent herpes simplex virus (HSV) infections in
       HIV-infected persons.
 DT    9605
 AU    Chang E; Absar N; Beall G; Harbor-UCLA Medical Center, Torrance, USA.
 SO    AIDS Patient Care. 1995 Oct;9(5):252-5. Unique Identifier : AIDSLINE
       AIDS/96156728
 AB    The purpose of this study was to determine the frequency of HSV
       infections and recurrences among HIV-infected patients and to examine
       different regimens for suppression of HSV recurrence. A randomized
       retrospective chart review of HIV-infected patients at a public hospital
       in Los Angeles County was conducted. We reviewed 224 patients' charts;
       26 percent had AIDS based on the 1987 CDC definition. HSV infection was
       documented as a clinical event in 51 records (23 percent). Patients with
       an AIDS diagnosis had a greater incidence (53 percent) of HSV infections
       than did those with a diagnosis of symptomatic or asymptomatic HIV
       infection (p < 0.001, Fisher's exact test). Recurrences of HSV occurred
       in 26 (51 percent) of the 51 HSV-infected persons during a period of
       1042 patient months. Eighteen patients who had received acyclovir
       suppression at 600 mg/day had three HSV recurrences in 382 patient
       months, whereas 14 who received 400 mg/day had eight recurrences in 282
       patient months (p = 0.02). HSV infections occur in 23 percent of
       HIV-infected patients, increasing to 53 percent in AIDS patients.
       Acyclovir suppression prevents recurrent HSV, and a dosage of 600 mg/day
       is more effective than 400 mg/day.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Acyclovir/*THERAPEUTIC
       USE  Adult  Antiviral Agents/*THERAPEUTIC USE  Decision Making  Female
       Herpes Simplex/COMPLICATIONS/DRUG THERAPY/EPIDEMIOLOGY/  *PREVENTION &
       CONTROL  Human  HIV Infections/*COMPLICATIONS  Male  Middle Age  Random
       Allocation  Recurrence  Retrospective Studies  Risk Factors  United
       States/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).