Document 0783
 DOCN  M9650783
 TI    Th1/Th2-like immunity and resistance to herpes simplex labialis.
 DT    9605
 AU    Spruance SL; Evans TG; McKeough MB; Thai L; Araneo BA; Daynes RA;
       Mishkin EM; Abramovitz AS; Department of Medicine, University of Utah,
       Salt Lake City 84132,; USA.
 SO    Antiviral Res. 1995 Sep;28(1):39-55. Unique Identifier : AIDSLINE
       MED/96105496
 AB    To investigate potential immunologic mechanisms of resistance to
       recurrent herpes simplex labialis, we assayed serum antibody titers and
       cultured peripheral blood mononuclear cell (PBMC) cytokine production
       among patients with a history of frequent episodes (H+S+), herpes
       simplex virus (HSV)-seropositive individuals without a history of herpes
       labialis (H-S+) and HSV-seronegative persons (H-S-). In addition, H+S+
       patients were exposed to experimental ultraviolet radiation (UVR) on the
       lips and the immunologic assay results compared among those who
       developed experimental lesions and those who did not. H+S+ patients were
       found to have higher median serum titers of HSV antibody and trends to
       lower levels of HSV-specific PBMC IFN-gamma and IL-2 than H-S+ control
       patients (123 vs 66, P = 0.04; 424 vs 548 pg/ml, P = 0.08; 14 vs 26
       pg/ml, P = 0.14, respectively). Correlation of the results with the
       occurrence of experimental lesions showed the inverse: the subgroup of
       H+S+ patients with UVR-induced lesions had lower titers of antibody and
       trends to higher levels of IFN-gamma and IL-2 than H+S+ patients who
       could not be induced (93 vs 149, P = 0.02; 501 vs 347 pg/ml, P = NS; 26
       vs 11 pg/ml, P = NS, respectively). The size and duration of UVR-induced
       lesions showed positive correlations with IFN-gamma and IL-2 levels (r =
       0.60-0.67, P = 0.02-0.04). Although the small number of patients limited
       the power of this study, the overall pattern of the findings suggests
       that a Th1-like cytokine response (IFN-gamma and IL-2 production) may be
       associated with resistance to naturally occurring episodes of herpes
       labialis. The development and severity of experimental UVR-induced
       herpes labialis appears to be regulated differently and may involve an
       immunopathologic mechanism.
 DE    Antibodies, Viral/BLOOD  Cells, Cultured  Cytokines/*IMMUNOLOGY  Herpes
       Labialis/*IMMUNOLOGY  Human  Immunity, Natural  Leukocytes,
       Mononuclear/IMMUNOLOGY  Lip Diseases/VIROLOGY  Recurrence  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Th1 Cells/*IMMUNOLOGY  Th2
       Cells/*IMMUNOLOGY  Ultraviolet Rays  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).