Document 0809
 DOCN  M9650809
 TI    Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell
       development [see comments]
 DT    9605
 AU    Guler ML; Gorham JD; Hsieh CS; Mackey AJ; Steen RG; Dietrich WF; Murphy
       KM; Department of Pathology, Washington University School of; Medicine,
       St. Louis, MO 63110, USA.
 SO    Science. 1996 Feb 16;271(5251):984-7. Unique Identifier : AIDSLINE
       MED/96172357
 CM    Comment in: Science 1996 Feb 16;271(5251):912-3
 AB    The genetic background of T lymphocytes influences development of the T
       helper (TH) phenotype, resulting in either resistance or susceptibility
       of certain mouse strains to pathogens such as Leishmania major. With an
       in vitro model system, a difference in maintenance of responsiveness of
       T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2
       mice. Although naive T cells from both strains initially responded to
       IL-12, BALB/c T cells lost IL-12 responsiveness after stimulation with
       antigen in vitro, even when cocultured with B10.D2 T cells. Thus,
       susceptibility of BALB/c mice to infection with L. major may derive from
       the loss of the ability to generate IL-12-induced TH1 responses rather
       than from an IL-4-induced TH2 response.
 DE    Animal  Cells, Cultured  Coculture  Disease Susceptibility/GENETICS
       Immunity, Natural/GENETICS  Interferon Type II/BIOSYNTHESIS
       Interleukin-12/*PHARMACOLOGY  Interleukin-4/BIOSYNTHESIS  Leishmania
       major/*IMMUNOLOGY  Leishmaniasis, Cutaneous/*IMMUNOLOGY  Lymphocyte
       Transformation  Mice  Mice, Inbred BALB C  Mice, Transgenic  Phenotype
       Receptors, Interleukin-2/BIOSYNTHESIS  Signal Transduction  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Th1 Cells/*IMMUNOLOGY  Th2
       Cells/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).