Document 0812
 DOCN  M9650812
 TI    Gamma Knife radiosurgery in AIDS-related primary central nervous system
       lymphoma.
 DT    9605
 AU    Nicolato A; Gerosa MA; Foroni R; Piovan E; Zampieri PG; Pasoli A; Giri
       MG; Iuzzolino P; Ghimenton C; Luzzati R; et al; Department of
       Neurosurgery, University Hospital of Verona, Italy.
 SO    Stereotact Funct Neurosurg. 1995;64 Suppl 1:42-55. Unique Identifier :
       AIDSLINE MED/96151255
 AB    The frequency of AIDS-associated primary central nervous system (PCNS)
       lymphoma is rapidly increasing in adults and children. In AIDS-related
       PCNS lymphoma, different authors have reported an overall poorer
       response rate to conventional radiation compared with immunocompetent
       patients. This poorer response consists of a significantly positive,
       although transient effect on survival following radiotherapy (XRT), with
       a poor toleration for prolonged whole-brain RT (WBR) and with
       radiation-induced changes within the normal CNS tissue on autopsy
       examinations after a course of XRT. These observations led us to
       consider highly focused single-session radiosurgical treatments as a
       potentially useful therapeutic modality for AIDS-associated PCNS
       lymphomas. A multi-institutional diagnostic and therapeutic protocol for
       the evaluation and treatment of AIDS patients with high-risk
       intracerebral space-occupying lesions has been developed at the
       University Hospital of Verona. Therapy is based on tumor biopsy. Tumors
       < or = 3.5 cm in diameter are subjected to Gamma Knife radiosurgery,
       whereas tumors < or = 4.5 cm are treated with stereotactic
       brachytherapy. At the Department of Neurosurgery, Verona, Italy, Gamma
       Knife treatment was performed in 2 cases of deep-seated histologically
       verified malignant non-Hodgkin's lymphoma. A short-term
       cliniconeuroradiological follow-up (2 months later) showed neurologic
       improvement and virtually complete disappearance of the tumor in both
       patients. The excellent local control and the well-tolerated
       single-session treatment and absence of brain toxicity signs on CT scan
       indicate a putative role for Gamma Knife radiosurgery in the treatment
       of these patients.
 DE    Adult  Case Report  Central Nervous System Neoplasms/ETIOLOGY/*SURGERY
       Female  Human  Lymphoma, AIDS-Related/*SURGERY  Male  *Radiosurgery
       Treatment Outcome  JOURNAL ARTICLE

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