Document 0825
 DOCN  M9650825
 TI    Mother-to-child transmission of human immunodeficiency virus type 1 and
       type 2 and dual infection: a cohort study in Banfora, Burkina Faso.
 DT    9605
 AU    Prazuck T; Yameogo JM; Heylinck B; Ouedraogo LT; Rochereau A;
       Guiard-Schmid JB; Lechuga P; Agranat P; Cot M; Malkin JE; et al; Groupe
       d'Etudes Epidemiologiques et Prophylactiques (GEEP),; Centre
       Hospitalier, France.
 SO    Pediatr Infect Dis J. 1995 Nov;14(11):940-7. Unique Identifier :
       AIDSLINE MED/96147525
 AB    A prospective cohort study on the mother-to-child transmission of human
       immunodeficiency virus type 1 (HIV1), type 2 (HIV2) and dual positivity
       (HIV1 + HIV2) was carried out in Banfora, West Burkina Faso. The study
       samples consist of 117 newborns of HIV-seropositive women matched to 234
       newborns of HIV-seronegative women. Among cases, 91 were born of
       HIV1-seropositive mothers, 15 were born of HIV2-seropositive mothers and
       11 were born of HIV1 and HIV2 dual-seropositive mothers and were
       included in an 18-month follow-up. Calculation of the mother-to-child
       transmission rate was according to the recommendations of the European
       Economic Community working group. The HIV1 mother-to-child transmission
       rate was estimated to be 27.8% (95% confidence interval (CI) 24.5 to
       32.4) with one method and 25.5% (95% CI 13.5 to 37.5) with a second
       method. For HIV2, this rate was estimated to be 29.5% (95% CI 26.0 to
       39.8) and was not statistically different from the HIV1 mother-to-child
       transmission rate. No case of transmission was observed in children born
       of dual seropositive mothers. Survival rate at month 18 was
       significantly lower for children born of HIV1 mothers: 83.7% (95% CI
       78.2 to 92.2). Survival rates were similar between children born of
       HIV2-seropositive (86.7), dual HIV1 + 2-positive (100) and seronegative
       mothers (92.0%). Findings suggest a higher mother-to-child transmission
       rate of HIV2 in children born in Burkina Faso than in Europe and a low
       clinical expression of HIV2 in children.
 DE    Adult  Africa  AIDS Serodiagnosis  Cohort Studies  *Disease
       Transmission, Vertical  Female  Follow-Up Studies  Human  HIV
       Infections/DIAGNOSIS/MORTALITY/*TRANSMISSION  HIV Seroprevalence
       HIV-1/*ISOLATION & PURIF  HIV-2/*ISOLATION & PURIF  Incidence  Infant
       Pregnancy  Pregnancy Complications, Infectious/*VIROLOGY  Prospective
       Studies  Support, Non-U.S. Gov't  Survival Rate  JOURNAL ARTICLE

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