Document 0829
 DOCN  M9650829
 TI    Detection of IgM antibodies to human herpesvirus 6 in Romanian children
       with nonprogressive human immunodeficiency virus disease.
 DT    9605
 AU    Nigro G; Luzi G; Krzysztofiak A; D'Orio F; Aiuti F; Pediatric Institute,
       La Sapienza University, Rome, Italy.
 SO    Pediatr Infect Dis J. 1995 Oct;14(10):891-4. Unique Identifier :
       AIDSLINE MED/96117428
 AB    The prevalence of human herpesvirus 6 (HHV-6) infection and the course
       of human immunodeficiency virus (HIV) disease were investigated in 25
       Romanian children with nosocomial HIV-1 infection. HHV-6 IgM and IgG
       antibodies were detected by enzyme immunoassay (EIA) and
       immunofluorescence assay (IFA) at the beginning of the study and after
       18 months, concomitantly with collection of virologic, immunologic and
       clinical data. The initial HHV-6 seropositivity was 92% by EIA and 76%
       by IFA, whereas final testing showed 100% positivity by EIA and 84% by
       IFA. Positive HHV-6 IgM antibodies were detected in 10 children (40%) by
       EIA and IFA. Of these 9 children (36%) by EIA and 6 (24%) by IFA had
       both initial and final IgM antibodies. Children with HHV-6 IgM
       antibodies had a higher prevalence of pneumonitis than those without
       (100% vs. 53.3%; P < 0.01). In addition they more frequently showed
       positive p24 antigen detection (67% vs. 40%) and positive HIV-1 culture
       (80% vs. 69%). Nevertheless the patients with HHV-6 IgM antibodies
       showed a slight increase in the final mean CD4+ T cell count (from 1.140
       to 1.185 x 10(6)/liter), whereas those with HHV-6 IgG alone showed a
       statistically significant (P = 0.01) decrease (from 1.395 to 968 CD4+
       T-cells x 10(6)/liter). Therefore current or recent HHV-6 infection, as
       revealed by positive HHV-6 IgM antibodies, appeared to be associated
       with the development of pneumonitis but not with progression of HIV
       disease. A possible competitive inhibition of HIV-1 by HHV-6 or a
       stimulating effect of HHV-6 on CD4+ T-cell production may be suggested.
 DE    Antibodies, Viral/*BLOOD  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS/EPIDEMIOLOGY  Child, Preschool  Cross Infection
       Disease Progression  Female  Fluorescent Antibody Technique, Indirect
       Herpesviridae Infections/COMPLICATIONS/*DIAGNOSIS/EPIDEMIOLOGY
       Herpesvirus 6, Human/*IMMUNOLOGY  Human  HIV Antibodies/BLOOD  HIV
       Infections/COMPLICATIONS/IMMUNOLOGY/*PHYSIOPATHOLOGY  *HIV-1  IgG/*BLOOD
       IgM/*BLOOD  Immunoenzyme Techniques  Infant  Male  Prevalence
       Romania/EPIDEMIOLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).