Document 0831
 DOCN  M9650831
 TI    Predicting perinatal human immunodeficiency virus infection by antibody
       patterns.
 DT    9605
 AU    Moodley D; Bobat RA; Coutsoudis A; Coovadia HM; Department of
       Paediatrics and Child Health, Faculty of Medicine,; University of Natal,
       Durban, South Africa.
 SO    Pediatr Infect Dis J. 1995 Oct;14(10):850-2. Unique Identifier :
       AIDSLINE MED/96117420
 AB    The evolution of human immunodeficiency virus type 1 (HIV-1) antibody
       titers determined by enzyme-linked immunosorbent assay between birth and
       18 months of age was investigated in 118 babies born to
       HIV-1-seropositive South African mothers. By 18 months 41 (34.7%)
       children were diagnosed as HIV-1-infected by standard criteria. All 77
       uninfected babies cleared maternal antibodies by 15 months; 94.5% of
       these babies seroreverted by 12 months. By 9 months of age a significant
       difference (P < 0.05) was noted between antibody decay rates in infected
       and uninfected children. Of the children subsequently shown to be
       uninfected, 95.8% demonstrated > or = 50% decay in antibody titers
       between 6 and 9 months; only 1 in the infected group showed a similar
       pattern (sensitivity, 97.8%; specificity, 93.8%). The approach of
       assessing the progression of antibody decay in infected and uninfected
       babies makes it a feasible and useful tool for estimating vertical
       transmission rates and diagnosis of perinatal HIV-1 infection earlier
       than standard practice.
 DE    Age of Onset  AIDS Serodiagnosis  Biological Markers/BLOOD  Cohort
       Studies  Disease Transmission, Vertical  Enzyme-Linked Immunosorbent
       Assay  Female  Human  HIV Antibodies/*BLOOD  HIV
       Infections/*DIAGNOSIS/IMMUNOLOGY/TRANSMISSION  HIV-1/*IMMUNOLOGY  Infant
       Infant, Newborn  Male  Predictive Value of Tests  Pregnancy  Pregnancy
       Complications, Infectious  Prospective Studies  Sensitivity and
       Specificity  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).