Document 0837
 DOCN  M9650837
 TI    Hypothesis explaining simultaneous development of acquired
       immunodeficiency syndrome and malignant tumors.
 DT    9605
 AU    Gogichadze GK; Dolidze TG; Research Institute of Haematology and Blood
       Transfusion, Tbilisi,; Republic of Georgia.
 SO    Med Hypotheses. 1995 May;44(5):307-8. Unique Identifier : AIDSLINE
       MED/96172196
 AB    A possible mechanism for explanation of the simultaneous development of
       acquired immunodeficiency syndrome (AIDS) and malignant tumors may be
       based on the cell-fusion process with the participation of
       immunocompetent cells. If the fusion proceeds with a high intensity,
       i.e. a great number of cells (including immunocompetent cells) are
       involved in the process, it will cause a rise in multinuclear
       formations-polykaryocytes. Since polykaryocytes are incapable of
       proliferation, their formation is equivalent to elimination of
       immunocompetent cells and may lead to immunodeficiency. If the intensity
       of fusion is low, the occurrence of binuclear formations-
       dikaryons-seems more frequent. We have shown (1) a possibility of the
       transformation of dikaryons into tumor cells under certain conditions
       and since immunocompetent cells are dominant by their phenotypic
       properties the malignant cells in AIDS should have mainly macrophage,
       lymphoid or intermediate morphology. Even low doses of various chemical
       carcinogens may cause malignancy by the formation of special defects in
       plasma membrane which promote cell fusion, whereas under high doses of
       carcinogens (or high intensity of their action) the formation of
       polykaryocytes and the development of immunodeficiency seem more
       probable, though it does not exclude the possibility of cancer
       development.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY/
       PHYSIOPATHOLOGY  Human  *Models, Biological
       Neoplasms/*COMPLICATIONS/IMMUNOLOGY/PHYSIOPATHOLOGY  Sarcoma,
       Kaposi's/ETIOLOGY/IMMUNOLOGY/PHYSIOPATHOLOGY  JOURNAL ARTICLE

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