Document 0838
 DOCN  M9650838
 TI    Multiple interspecies transmissions of human and simian T-cell
       leukemia/lymphoma virus type I sequences.
 DT    9605
 AU    Crandall KA; Department of Zoology, University of Texas at Austin
       78712-1064,; USA.
 SO    Mol Biol Evol. 1996 Jan;13(1):115-31. Unique Identifier : AIDSLINE +
 AB    Using two sets of nucleotide sequences of the human and simian T-cell
       leukemia/lymphoma virus type I (HTLV-I/STLV-I), one consisting of 522 bp
       of the env gene from 70 viral strains and the other a 140-bp segment
       from the pol gene of 52 viral strains, I estimated cladograms based on a
       statistical parsimony procedure that was developed specifically to
       estimate within-species gene trees. An extension of a nesting procedure
       is offered for sequence data that forms nested clades used in hypothesis
       testing. The nested clades were used to test three hypotheses relating
       to transmission of HTLV/STLV sequences: (1) Have cross-species
       transmissions occurred and, if so, how many? (2) In what direction have
       they occurred? (3) What are the geographic relationships of these
       transmission events? The analyses support a range of 11-16 cross-species
       transmissions throughout the history of these sequences. Additionally,
       outgroup weights were assigned to haplotypes using arguments from
       coalescence theory to infer directionality of transmission events.
       Conclusions on geographic origins of transmission events and particular
       viral strains are inconclusive due to small samples and inadequate
       sampling design. Finally, this approach is compared directly to results
       obtained from a traditional maximum parsimony approach and found to be
       superior at establishing relationships and identifying instances of
       transmission.
 DE    Animal  Gene Transfer  *Genes, Viral  Human  HTLV-I/*GENETICS  Phylogeny
       Retroviruses, Simian/*GENETICS  Sequence Analysis  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, Non-P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).