Document 0840
 DOCN  M9650840
 TI    Natural history of HIV-1 infection and predictors of survival in a
       cohort of HIV-1 seropositive injecting drug users.
 DT    9605
 AU    Brown LS Jr; Siddiqui NS; Chu AF; Division of Medical Services,
       Evaluation and Research, Addiction; Research and Treatment Corporation,
       Brooklyn, New York 11201,; USA.
 SO    J Natl Med Assoc. 1996 Jan;88(1):37-42. Unique Identifier : AIDSLINE
       MED/96166230
 AB    Injecting drug users represent a pivotal and increasing component of
       acquired immunodeficiency syndrome (AIDS) case reporting in the United
       States. This article describes the natural history of human
       immunodeficiency virus (HIV) disease in a New York City cohort of 328
       HIV-infected injecting drug users. The study sample of nearly two-thirds
       men (predominately African Americans and Latino Americans) underwent
       follow-up from December 1988 through December 1993. Male injecting drug
       users reported a longer injecting drug use history and were more likely
       to share needles/works than female injecting drug users. Eighty-nine of
       328 study subjects died during the 5 years of observation. Comparing
       African Americans and Latinos, race/ethnicity was not related to
       survival. Survival was related to baseline CD4 count and hemoglobin
       level. Zidovudine use and PCP prophylaxis did not predict survival.
       Because of the continuing and increasing impact of HIV disease on
       injecting drug users and communities of color, there remains an
       unquestionable need to develop effective prevention programs, to
       understand the natural history of HIV disease, and to develop
       appropriate therapeutic interventions to treat those with HIV disease.
 DE    Adult  CD4 Lymphocyte Count  Female  Human  HIV
       Infections/COMPLICATIONS/*EPIDEMIOLOGY/MORTALITY  *HIV-1  Male  Middle
       Age  New York City/EPIDEMIOLOGY  Proportional Hazards Models
       Prospective Studies  *Sex Behavior  Substance Abuse,
       Intravenous/*COMPLICATIONS/MORTALITY  Survival Analysis  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).