Document 0841
 DOCN  M9650841
 TI    Photodynamic inactivation of cell-free HIV strains by a red-absorbing
       chlorin-type photosensitizer.
 DT    9605
 AU    Grandadam M; Ingrand D; Huraux JM; Aveline B; Delgado O; Vever-Bizet C;
       Brault D; Laboratoire de Virologie du CERVI, CNRS EP 57, Hopital de la;
       Pitie-Salpetriere, Paris, France.
 SO    J Photochem Photobiol B. 1995 Dec;31(3):171-7. Unique Identifier :
       AIDSLINE MED/96141459
 AB    We have investigated the photodynamic activity of a new chlorin-type
       photosensitizer on a reference human immunodeficiency virus type 1
       (HIV-1) strain, two wild-type HIV-1 isolates and two drug-resistant
       HIV-1 isolates. This chlorin was highly effective for the inactivation
       of free viruses, as assessed by two different quantitative cell culture
       assays. In the absence of blood components, all the HIV strains,
       including wild-type and drug-resistant mutant isolates, were totally
       inactivated using 30 micrograms ml-1 of chlorin and 0.75 J cm-2 of 661
       nm light. Successful killing of HIV-1 strains in either plasma or whole
       blood was also obtained by increasing the chlorin concentration
       moderately. Our results demonstrate the antiviral efficiency of this
       chlorin, suggesting the potential application of dye-sensitized
       photoirradiation to decontaminate blood products.
 DE    Blood  Buffers  Cell Line  Cell-Free System  Cells, Cultured
       Deuteroporphyrins/CHEMISTRY/PHARMACOLOGY  Hela Cells  Human  HIV
       Infections/VIROLOGY  HIV-1/*DRUG EFFECTS/ISOLATION & PURIF/*RADIATION
       EFFECTS  *Light  Photosensitizing Agents/*PHARMACOLOGY  Plasma
       Porphyrins/CHEMISTRY/*PHARMACOLOGY  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

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