Document 0844
 DOCN  M9650844
 TI    Characterization of cerebral white matter lesions of HTLV-I-associated
       myelopathy/tropical spastic paraparesis in comparison with multiple
       sclerosis and collagen-vasculitis: a semiquantitative MRI study.
 DT    9605
 AU    Godoy AJ; Kira J; Hasuo K; Goto I; Department of Neurology, Kyushu
       University, Fukuoka, Japan.
 SO    J Neurol Sci. 1995 Nov;133(1-2):102-11. Unique Identifier : AIDSLINE
       MED/96154913
 AB    The brain lesions were studied by magnetic resonance imaging (MRI) in 29
       HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), 43
       multiple sclerosis (MS) (11 with a primary progressive course: PPMS and
       32 with a relapsing-remitting course: RRMS), 23 collagen-vasculitis and
       54 HTLV-I-seronegative patients with other non-inflammatory neurological
       disorders (OND), according to the size of the lesions and their location
       in the brain (deep and subcortical white matter, periventricular white
       matter, infratentorial region and gray matter). Semiquantitative MRI
       analyses revealed the followings. (1) The frequency of either small or
       large lesions located in the periventricular as well as deep and
       subcortical white matter was significantly higher in HAM/TSP than in OND
       patients (p < 0.006, chi 2 test). In addition, the number of small
       lesions in the deep and subcortical, and periventricular white matter
       was significantly greater in HAM/TSP than in OND patients (p < 0.0003,
       Mann-Whitney U-test). (2) The HAM/TSP patients significantly exceeded
       the collagen-vasculitis patients in the frequency and the number of
       small lesions located in the periventricular region (p < 0.0001, chi 2
       test, and p < 0.05, Mann-Whitney U-test, respectively), although no
       difference was found in case of those in the deep and subcortical white
       matter. (3) The HAM/TSP group had a lower frequency of small deep and
       subcortical white matter, small infratentorial and large periventricular
       lesions than the entire MS group (p < 0.05, chi 2 test). The PPMS group
       greatly exceeded the HAM/TSP group in the number of MRI lesions in all
       brain regions (p < 0.05, Mann-Whitney U-test), whereas RRMS and HAM/TSP
       patients showed a similar number of lesions (p > 0.1, Mann-Whitney
       U-test). Both the difference between HAM/TSP and collagen-vasculitis and
       the similarities between HAM/TSP and RRMS in the MRI features suggest
       that although all commonly have a vasculitic process as a necessary
       component, some other factor, probably with demyelinating effects, is
       operative HAM/TSP.
 DE    Adult  Aged  Brain/METABOLISM/*PATHOLOGY  Cerebellum/PATHOLOGY  Cerebral
       Ventricles/PATHOLOGY  Collagen/*ANALYSIS  Comparative Study  Female
       Human  *Magnetic Resonance Imaging  Male  Middle Age  Multiple
       Sclerosis/*PATHOLOGY  Paraparesis, Tropical Spastic/*PATHOLOGY
       Vasculitis/METABOLISM/*PATHOLOGY  CLINICAL TRIAL  CONTROLLED CLINICAL
       TRIAL  JOURNAL ARTICLE

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