Document 0853
 DOCN  M9650853
 TI    Methyl inosine monophosphate (MIMP) augments T-lymphocyte mitogen
       responses and reverses various immunosuppressants.
 DT    9605
 AU    Hadden EM; Wang Y; Sosa M; Coffey RG; Giner-Sorolla A; Hadden JW;
       Immunopharmacology Division, University of South Florida Medical;
       College, Tampa 33612, USA.
 SO    Int J Immunopharmacol. 1995 Sep;17(9):763-70. Unique Identifier :
       AIDSLINE MED/96153671
 AB    Methyl inosine monophosphate (MIMP) augments preferentially the in vitro
       responses of human and murine lymphocytes to a T-cell mitogen such as
       phytohemagglutinin (PHA) and inconsistently to a B-cell mitogen such as
       pokeweed or lipopolysaccharide (LPS). In a normal
       interleukin-2-dependent cell line (CTLL), MIMP showed little or no
       effect on IL-2 action; however, in a murine CTLL line exhibiting
       impaired responses to IL-2, MIMP stimulated thymidine incorporation and
       restored the response to IL-2. MIMP augments the PHA responses of both
       CD4+ and CD8+ human peripheral blood T-cells. The effect of MIMP to
       augment the PHA response of human lymphocytes is paralleled by the
       parent molecule, IMP. MIMP, but not IMP, is resistant to hydrolysis by
       5'nucleotidase; thus, MIMP appears to be a protected analogue of IMP
       which is capable of in vivo action. MIMP (100 micrograms/ml) augments
       the PHA responses of 15 to 24 elderly humans. MIMP also augments the PHA
       responses of eight HIV-infected pre-AIDS patients but not of eight AIDS
       patients. When PHA responses of human lymphocytes are suppressed in
       vitro by an HIV-derived immunosuppressive peptide, interferon alpha, or
       prostaglandin PGE2, MIMP (0.1-100 micrograms/ml) progressively restores
       the depressed response; however, when the suppression is severe (greater
       than 50%), MIMP cannot restore the response. These data indicate that
       MIMP potentiates normal T-lymphocyte mitogen responses and restores
       those impaired by a variety of inflammatory and immunosuppressive
       influences.
 DE    Animal  Antiviral Agents/*PHARMACOLOGY  Cells, Cultured
       Dinoprostone/PHYSIOLOGY  Dose-Response Relationship, Drug  Human  HIV
       Infections/DRUG THERAPY  Immunosuppressive Agents/*ANTAGONISTS & INHIB
       Inosine Monophosphate/*ANALOGS & DERIVATIVES/PHARMACOLOGY
       Interferon-alpha/DRUG EFFECTS  Mice  Mitogens/*PHYSIOLOGY
       Spleen/CYTOLOGY/DRUG EFFECTS  Support, Non-U.S. Gov't
       T-Lymphocytes/*DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).