Document 0872
 DOCN  M9650872
 TI    Synthesis and conformational analysis of pyrimidine nucleoside analogues
       with a rigid sugar moiety.
 DT    9605
 AU    Bjorsne M; Szabo T; Samuelsson B; Classon B; Department of Organic
       Chemistry, Stockholm University, Sweden.
 SO    Bioorg Med Chem. 1995 Apr;3(4):397-402. Unique Identifier : AIDSLINE
       MED/96172305
 AB    In order to obtain rigidity within the sugar moiety of nucleosides, some
       bicyclic pyrimidine nucleoside analogues were synthesized starting from
       cyclopentanone. The C-3' is fused to C-4' via a propylene linker in
       order to obtain a [3.3.0]-bicyclic ring system wherein the sugar moiety
       should be restricted to mainly the C-1'-exo conformation.
 DE    Antiviral Agents/*CHEMISTRY/CHEMICAL SYNTHESIS/PHARMACOLOGY
       Chromatography  Cyclopentanes/*CHEMISTRY  Cytidine/CHEMISTRY  Human
       HIV-1/DRUG EFFECTS/ENZYMOLOGY  Molecular Conformation  Nuclear Magnetic
       Resonance  Pyrimidines/*CHEMISTRY  Reverse Transcriptase
       Inhibitors/PHARMACOLOGY  Software  Structure-Activity Relationship
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).