Document 0875
 DOCN  M9650875
 TI    [Reevaluation of the sensitivity of screening assays for anti-HIV
       antibodies. The Retrovirus Work Group of the SFTS. French Society of
       Blood Transfusion]
 DT    9605
 AU    Courouce AM; Institut National de la Transfusion Sanguine, Paris.
 SO    Transfus Clin Biol. 1995;2(5):395-408. Unique Identifier : AIDSLINE
       MED/96151343
 AB    A comparative evaluation of the sensitivity of anti-HIV screening assays
       has been recently performed with a selected panel including all the
       actually known difficulties of HIV serology: Very recent seroconversions
       (per-seroconversions) and recent HIV1/M seroconversions, HIV1/M
       seropositive with a subtype different from B, HIV1 group 0 and HIV2. The
       criteria of sensitivity were to recognize as positive all the
       seropositive samples and at least 2 of the 8 per-seroconversions. The 18
       combined ELISA fulfilled these criteria, except for one assay with a
       deficient HIV2 sensitivity. However, all these assays do not have the
       same level of sensitivity. The most important differences were observed
       with the pre-seroconversion samples, the number of positive results on
       such samples varying from 2 to 8. The capacity of a screening assay to
       early detect an HIV-infected subject is a supplementary criterium to
       retain, particularly in blood transfusion screening, in order to shorten
       the window period.
 DE    English Abstract  Enzyme-Linked Immunosorbent Assay  Human  HIV
       Antibodies/*BLOOD  HIV Seropositivity/*DIAGNOSIS  Mass
       Screening/*METHODS  Sensitivity and Specificity  Serodiagnosis/*METHODS
       JOURNAL ARTICLE

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