Document 0881
 DOCN  M9650881
 TI    Immunologic type of thyroid lymphoma in an adult T-cell leukemia endemic
       area in Japan.
 DT    9605
 AU    Ohsawa M; Noguchi S; Aozasa K; Department of Pathology, Osaka University
       School of Medicine,; Suita, Japan.
 SO    Leuk Lymphoma. 1995 Apr;17(3-4):341-4. Unique Identifier : AIDSLINE
       MED/96172088
 AB    Our previous study showed that thyroid non-Hodgkin's lymphoma (TL) in an
       adult T-cell leukemia/lymphoma (ATL) non-endemic area were exclusively
       B-cell derived. The present study was carried out to examine whether TL
       in an ATL endemic area are also exclusively of B-cell type. Eight cases
       with TL admitted to the hospital situated in an ATL endemic area were
       studied: they were all female with an age range from 50 to 75 (median
       67) years. Histologically four of the eight cases showed a follicular
       pattern. Immunophenotypic study revealed all but one case to be of
       B-cell nature: CD3-, 4-, 8-, 20+, 22+, 45RA+, 45RO-, L22-, L24+/-, L28+.
       Neoplastic cells in one case with the histology of diffuse large cell
       lymphoma showed a CD3+, 4+, 8-, 20-, 22-, 45RA-, 45RO+/-, L22-, L24-,
       L28-, indicating a helper T-cell phenotype. Genotypic study showed
       rearrangement of T-cell beta-chain receptor in this case. This case also
       had antibodies against HTLV-1 in the serum. This case shows that it is
       also possible to develop T-cell TL in an endemic ATL area.
 DE    Aged  Female  Gene Rearrangement  Genotype  Human  Immunohistochemistry
       Immunophenotyping  Japan/EPIDEMIOLOGY  Leukemia-Lymphoma, T-Cell, Acute,
       HTLV-I-Associated/EPIDEMIOLOGY/  GENETICS/*IMMUNOLOGY  Lymphoma,
       Non-Hodgkin's/EPIDEMIOLOGY/GENETICS/*IMMUNOLOGY  Middle Age  Support,
       Non-U.S. Gov't  Thyroid Neoplasms/EPIDEMIOLOGY/GENETICS/*IMMUNOLOGY
       JOURNAL ARTICLE

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