Document 0882
 DOCN  M9650882
 TI    HIV interactions with cells of the nervous system.
 DT    9605
 AU    Dubois-Dalcq M; Altmeyer R; Chiron M; Wilt S; Departement de Virologie,
       Institut Pasteur, Paris, France.; mdalcq@pasteur.fr
 SO    Curr Opin Neurobiol. 1995 Oct;5(5):647-55. Unique Identifier : AIDSLINE
       MED/96163703
 AB    HIV can invade the CNS, where it replicates principally in macrophages.
       Yet, neurological disease is more often correlated with levels of
       neurotoxins or tumor necrosis factor alpha than with viral replication
       or specific viral determinants in brain. In experimental systems, HIV
       glycoprotein affects functions of uninfected microglia and astrocytes to
       eventually cause neuronal death. While the cellular basis of cognitive
       and neurological dysfunction are unravelled in the simian
       immunodeficiency virus model, the molecular mechanisms of HIV
       neurotoxicity are being studied in newly developed mouse models.
 DE    Animal  Central Nervous System/*VIROLOGY  HIV/*PHYSIOLOGY
       Microglia/*VIROLOGY  Support, Non-U.S. Gov't  Virus
       Replication/*PHYSIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).