Document 0888
 DOCN  M9650888
 TI    Characterization of distribution of T lymphocyte subsets and activated T
       lymphocytes infiltrating into sarcoid lesions [see comments]
 DT    9605
 AU    Kita S; Tsuda T; Sugisaki K; Miyazaki E; Matsumoto T; Third Department
       of Internal Medicine, Oita Medical University.
 SO    Intern Med. 1995 Sep;34(9):847-55. Unique Identifier : AIDSLINE
       MED/96121647
 CM    Comment in: Intern Med 1995 Sep;34(9):819
 AB    We studied the relationship between various T lymphocyte functions and
       granuloma formation in 5 lung tissue and 4 lymph node tissue samples
       from patients with sarcoidosis by immunohistological methods. In the
       lesion of sarcoidosis, T cells were positive for alpha beta TCR, but
       gamma delta TCR-positive T cells were rarely observed. The results of
       analysis of functional subsets showed that T cells in the internal area
       of granuloma were predominantly helper/inducer subset (CD4+CD45RA-). On
       the other hand, cytotoxic T cells (CD8+CD45RA-CD11b-) were present in
       abundance in the outer boundaries of granuloma. In addition,
       suppressor-inducer T cells (CD4+CD45RA+) were present in the surrounding
       areas. However, T cells of various subsets were present sporadically
       outside the granulomas. We also studied the distribution of T cells
       expressing activation-related antigens. The results showed that T
       lymphocytes in the internal area of granulomas more frequently had these
       antigens than did T lymphocytes in the external area. These findings
       suggested that T cells infiltrating into the sarcoidosis lesion
       demonstrated a layer-like distribution based on functional subsets.
       These findings also confirm that activated T cells were more abundantly
       distributed in the internal area of sarcoid granuloma than in the
       external area.
 DE    Antibodies, Monoclonal  Antigens, CD/*IMMUNOLOGY  CD4-CD8 Ratio
       Fluorescent Antibody Technique  Human  Retrospective Studies
       Sarcoidosis/*IMMUNOLOGY/PATHOLOGY  T-Lymphocyte
       Subsets/*IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).