Document 0909
 DOCN  M9650909
 TI    Fas and FasL in the homeostatic regulation of immune responses.
 DT    9605
 AU    Lynch DH; Ramsdell F; Alderson MR; Immunex Corporation, Seattle, WA
       98101, USA.
 SO    Immunol Today. 1995 Dec;16(12):569-74. Unique Identifier : AIDSLINE
       MED/96114390
 AB    Studies of the biological effects of Fas signaling, using transformed
       cell lines as targets, indicate that ligation of the Fas receptor
       induces an apoptotic death signal. Chronically activated normal human T
       cells are also susceptible to Fas-mediated apoptosis. However,
       interactions between Fas and Fas ligand can also yield a costimulatory
       signal. Here, David Lynch, Fred Ramsdell and Mark Alderson present a
       model for the role of As and FasL in the homeostatic regulation of
       normal immune responses. They discuss how dysregulation of the Fas
       apoptotic pathway may contribute to certain disease states, including
       autoimmune disease and human immunodeficiency virus (HIV)-induced
       depletion of CD4+ T cells.
 DE    Animal  Antibody Formation  Antigens, CD95/ADVERSE EFFECTS/*PHYSIOLOGY
       Homeostasis/*IMMUNOLOGY  Human  Immunity, Cellular  Ligands  Membrane
       Glycoproteins/ADVERSE EFFECTS/*PHYSIOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).