This is GEPASI 2.0, a general purpose simulator of metabolic pathways.
It is a directed towards research and education; it is meant to be a
very useful tool for modelling biochemical pathways, chemical 
reactions,etc. GEPASI is free software covered by the GNU general
public license, version 1.

This version of GEPASI runs under MS-Windows 3.1 in 386 enhanced mode, 
on 80386SX and above microprocessors. A maths co-processor is not 
needed but should accelerate the simulations by at least a factor of
10.

To install GEPASI unzip all the files to a diskette or to a hard-disk 
directory; there is no need to do this if you have received GEPASI in
a diskette. Next go to Windows' program manager, select File-Run, and
enter SETUP.EXE (don't forget to include the complete path of the
disk drive and directory where you have unzipped it to).

In order to simulate bichemical pathways, the user must first define
the reactions that are part of the pathway, all its parameters and 
initial concentrations of the metabolites (chemical species). GEPASI
then determines the dynamics and steady state (if there is one),
including the coefficients defined in Metabolic Control Analysis.
GEPASI can be used to study metabolic regulation, chemical and enzyme
kinetics including oscillatory (limit cycle) and chaotic reactions.

The file GEPASI.WRI contains a cut-down version of a paper to appear
in "Modern trends in Biothermokinetics", edited by J.-P. Mazat, S.
Schuster and M. Rigoulet and published by Plenum Press with a short
description of GEPASI. Another more detailed paper is being submitted 
to the journal "Computer Applications in the Biosciences".

For more detailed information see the help file (GEPASI.HLP). The 
subjects of metabolic simulation and metabolic control analysis are 
discussed in the mailing list btk-mca. To subscribe to this list send 
a mail message to biosci@net.bio.net, post to the list to 
btk-mca@net.bio.net.

GEPASI 2.0 (c) 1898,1992 by Pedro Mendes.
prm@aber.ac.uk