Document 0859
 DOCN  M9540859
 TI    The influence of adriamycin on the CD4+ and CD8+ cells in the course of
       trichinellosis in mice.
 DT    9504
 AU    Karmanska K; Houszka M; Mista D; Stefaniak E; W. Stefanski Institute of
       Parasitology, Polish Academy of; Sciences, Wroclaw.
 SO    Wiad Parazytol. 1994;40(4):363-7. Unique Identifier : AIDSLINE
       MED/95133318
 AB    The effect of adriamycin on the behaviour of CD4+ and CD8+ cells in the
       course of trichinellosis in mice has been studied. The animals infected
       with 200 larvae per mouse were administered intraperitoneally adriamycin
       (Adriblastin from Farmitalia) at 1st and 28th day post infection (dpi),
       in a dosis of 0.2 mg. The mice were killed weakly for 6 weeks and then
       at the 60th dpi. The examinations were made on histologic sections from
       the spleen, mesenteric lymph node, jejunum and masseter muscle using
       immunofluorescent and immunoenzymatic methods with monoclonal antibody.
       The mice receiving adriamycin exhibited more CD8+ cells in the
       intestinal mucosa and by the end of the experiment also in the muscles
       in comparison with the control animals, which, however, did not affect
       the course of the infection.
 DE    Animal  CD4-Positive T-Lymphocytes/*DRUG EFFECTS  CD8-Positive
       T-Lymphocytes/*DRUG EFFECTS  Doxorubicin/*PHARMACOLOGY  Jejunum/DRUG
       EFFECTS/IMMUNOLOGY/PARASITOLOGY  Lymph Nodes/DRUG EFFECTS/IMMUNOLOGY
       Male  Mesentery  Mice  Muscle, Skeletal/DRUG EFFECTS/PARASITOLOGY
       Spleen/DRUG EFFECTS/IMMUNOLOGY  Trichinosis/*IMMUNOLOGY  JOURNAL ARTICLE

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