Document 0860
 DOCN  M9540860
 TI    CD4+ and CD8+ cells in mice infected with Trichinella spiralis and
       treated with cyclosporine A.
 DT    9504
 AU    Karmanska K; Houszka M; Mista D; Stefaniak E; W. Stefanski Institute of
       Parasitology, Polish Academy of; Sciences, Wroclaw.
 SO    Wiad Parazytol. 1994;40(4):357-62. Unique Identifier : AIDSLINE
       MED/95133317
 AB    The mice infected with 200 Trichinella spiralis larvae were injected
       intraperitoneally with Cyclosporine A (CyA) between 14-18 days post
       infection (dpi). The drug was administered in a dosis of 50 mg/kg/day.
       The animals were killed at 21, 28, 35, 42 and 60 dpi and the fragments
       of spleen, mesenteric lymph node, jejunum and musculus masseter were
       sectioned in a cryostat and fixed in acetone. The slides were examined
       with monoclonal sera by the immunofluorescent or immunoenzymatic method.
       It was found that the number of CD4+ cells in the control and in the
       CyA-treated mice was similar but in the animals receiving the drug the
       reaction was less intensive. The stimulation of CD8+ cells of CyA
       treated mice--especially in the jejunum--was stronger than in the
       control animals. This fact is important because the CD8+ cells are the
       APC cells in this organ.
 DE    Animal  Cyclosporine/*PHARMACOLOGY  CD4-Positive T-Lymphocytes/*DRUG
       EFFECTS  CD8-Positive T-Lymphocytes/*DRUG EFFECTS  Fluorescent Antibody
       Technique  Immunoenzyme Techniques  Jejunum/DRUG
       EFFECTS/IMMUNOLOGY/PARASITOLOGY  Lymph Nodes/DRUG EFFECTS/IMMUNOLOGY
       Male  Masseter Muscle/DRUG EFFECTS/IMMUNOLOGY/PARASITOLOGY  Mice
       Spleen/DRUG EFFECTS/IMMUNOLOGY  *Trichinella spiralis
       Trichinosis/*IMMUNOLOGY  JOURNAL ARTICLE

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