Document 0863
 DOCN  M9540863
 TI    Efficient synthesis of viral nucleic acids following monocyte infection
       by HIV-1.
 DT    9504
 AU    Heinzinger N; Baca-Regen L; Stevenson M; Gendelman HE; Department of
       Pathology and Microbiology, University of Nebraska; Medical Center,
       Omaha 68198-5120.
 SO    Virology. 1995 Jan 10;206(1):731-5. Unique Identifier : AIDSLINE
       MED/95133219
 AB    The replication of human immunodeficiency virus type 1 in mononuclear
       phagocytes (blood monocytes, tissue macrophages, and dendritic cells) is
       an important feature of HIV-1 pathogenesis. Although most primary HIV-1
       isolates are able to productively infect monocytes, some reports suggest
       that rates of viral DNA synthesis and virus replication are reduced in
       HIV-1-infected monocytes as compared to infected T cells. In this study
       we compare kinetics of viral DNA synthesis in CD4+ T cells and monocytes
       following HIV-1 infection. Our results indicate that reverse
       transcription of viral nucleic acids following infection of monocytes
       occurs at rates equal to or greater than that observed following
       infection of T cells. These studies reveal no postentry restrictions to
       HIV-1 replication following infection in monocytes. Moreover, the
       results support the notion that both monocytes and CD4+ T cells are
       equally permissive for virus replication in infected individuals.
 DE    Cells, Cultured  Human  HIV-1/DRUG EFFECTS/*PHYSIOLOGY
       Monocytes/*VIROLOGY  Nucleic Acids/*BIOSYNTHESIS/GENETICS  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Transcription, Genetic
       Virus Replication  Zidovudine/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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